منابع مشابه
Pyrophosphate, alkaline phosphatase, and vascular calcification.
Vascular Calcification To the Editor: In their editorial on vascular calcification, Demer and Tintut1 incorrectly state that pyrophosphate reduces calcification by inhibiting alkaline phosphatase. Actually, the opposite is true. Alkaline phosphatase promotes calcification by reducing pyrophosphate levels. Pyrophosphate is a substrate for alkaline phosphatase,2 and this enzyme regulates pyrophos...
متن کاملCalpain-1 Mediated Disorder of Pyrophosphate Metabolism Contributes to Vascular Calcification Induced by oxLDL
We previously reported that oxidized low density lipoprotein (oxLDL) accelerated the calcification in aorta of rats and rat vascular smooth muscle cells (RVSMCs). However, the molecular mechanism underlying the acceleration remains poorly understood. The present study aimed to investigate the role of calpain-1, Ca2+-sensitive intracellular cysteine proteases, in the vascular calcification of ra...
متن کاملPlasma pyrophosphate and vascular calcification in chronic kidney disease.
BACKGROUND Pyrophosphate (PPi) is a potent inhibitor of vascular calcification and may be deficient in renal failure. We sought to determine whether plasma PPi is affected by dialysis or the mode of dialysis and whether it correlates with vascular calcification. METHODS PPi was measured in plasma samples stored from a recent study of vascular calcification in 54 HD patients, 23 peritoneal dia...
متن کاملBone pyrophosphate in uremia and its association with extraosseous calcification.
The mean bone pyrophosphate was 0.360 +/- 0.15 mg/g in 8 controls and 1.22 +/- 1.39 mg/g bone in 27 uremic patients (P less than 0.0025). 13 of the 27 uremic patients had bone pyrophosphate levels greater than 2 SD above control values. The ash content of uremic bones with increased pyrophosphate levels (group II) was 56 +/- 9% as compared to 64 +/- 2% in control bones (P less than 0.01) and 60...
متن کاملBone metabolism and vascular calcification.
Osteoporosis and atherosclerosis are chronic degenerative diseases which have been considered to be independent and whose common characteristic is increasing incidence with age. At present, growing evidence indicates the existence of a correlation between cardiovascular disease and osteoporosis, irrespective of age. The morbidity and mortality of osteoporosis is mainly related to the occurrence...
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ژورنال
عنوان ژورنال: Aging
سال: 2018
ISSN: 1945-4589
DOI: 10.18632/aging.101703